Lymph liquid biopsy:
Novel. Near. Now.

Novel

For the first time, non-invasive liquid biopsy techniques can unlock lymphatic insights to aid in post-operative treatment decisions.

The lymphatic system is the most common means of metastasis in over 90% of cancer cases. Lymphatic metastasis begins in the nodes nearest the tumor where cancer cells can grow and eventually spread via the circulatory system.

Primary means of
metastasis by cancer type

  • Breast
  • Prostate
  • Lung
  • Colorectal
  • Melanoma
  • Bladder
  • Renal
  • Uterine
  • Pancreatic
  • Head and neck
  • Thyroid
  • Liver
  • Stomach
  • Esophageal
  • Blood
  • Bone
  • Sarcoma
  • Ovarian/fallopian
diagram-transparent-min

Near

Understanding local risk requires a local analyte.  Lymph-rich surgical drain fluid is the most proximal biofluid to the recently resected tumor, enabling assessment of recurrence risk before cancer spreads.

Droplet sequences the fluid that drains from an integrated network of tissue, nodes, and lymphatic channels in the locoregional area.

Droplet’s assay can detect molecular-level disease, in-transit metastasis, and positive nodes that may have been missed during surgery or pathological review.

Now

Droplet delivers highly sensitive results early enough to aid in treatment decisions during the curative timeframe.

Blood-based ctDNA markers of molecular residual disease can identify recurrence but rarely in time to impact treatment with curative intent or with the sensitivity necessary to detect locoregional spread.

Lymph liquid biopsy takes place immediately after surgery, allowing care teams to assess recurrence risk at the most consequential time point and design adjuvant treatment plans for every individual patient.

Pipeline

Publications

AACR
Accelerating minimal residual disease (MRD) detection through GPU-accelerated genomic analysis using NVIDIA Parabricks
AACR
Multi-omics in postoperative lymphatic exudate in HPV-negative head and neck cancer
AACR
Postoperative lymphatic exudate as a proximal liquid biopsy source in muscle-invasive bladder cancer
AACR
Lymphatic exudate is a novel source of tumor-associated immune cells
AACR
A novel extraction method for enrichment of circulating cell-free DNA
NVIDIA
Droplet Biosciences Accelerates Residual Cancer Detection with NVIDIA Parabricks
Clinical Cancer Research
Demonstrating performance of proximal lymph fluid as a viable source for ctDNA analysis for HPV(-) Head and Neck Cancer
AACR
Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer
AACR
Postoperative lymphatic exudate in HPV-negative head and neck cancer detects recurrence prior to adjuvant treatment selection
AMP
ctDNA analysis of lymph detects minimal residual disease and correlates with recurrence in HPV-head and neck cancer patients
AACR
Detection of minimal residual disease in lymph predicts recurrence in HPV-negative head and neck cancer patients
AACR
Unveiling Liquid Gold: Lymph as an HPV Marker in OPSCC to Guide Treatment Decisions